CANCERS BRONCHIQUES A PETITES CELLULES

CANCERS BRONCHIQUES A PETITES CELLULES
ESSAIS COMPARANT LA CHIMIOTHERAPIE AVEC OU SANS IRRADIATION THORACIQUE DANS LES MALADIES LIMITEES

Référence	chimiothérapie	RT Gy	nb pts	SM CT+ RT	SM CT	p
Fox, 1980	VAC x 10	séquentielle 40	73	68s	62s	ND
Souhami, 1984	VAC~CPA-MTX x 12	séquentielle 40	130			ND
Osterlind, 1986	CPA-MTX-VCR-CCNU x 18 mois	concomitante 40	145	42s	52s	0,05
Ohnoshi, 1986	CPA-MTX-VCR-PCZ~VP16-ADR x 6	séquentielle 40	50	12m	15m	NS
Bunn, 1987	CMC~CDDP-ADR-VCR x 8	concomitante 40	96	15m	11m	0,03
Perry, 1987	VAC-VP16 x 18 mois	concomitante 50	489	14m	14m	0,001
Kies, 1987	VAC-MTX-VP16~ CDDP-VP16 x 6	séquentielle 48	93			0,86
Nou, 1988	VAC-MTX~CMV-CCNU x 24	séquentielle 40	56	15m	15m	NS
Birch I, 1988	VAC x 6	fractionnée 40	291	54s	46s	0,04
Birch II, 1988	VAC x 6	fractionnée 45	369	45s	51s	0,12
Kraft, 1990	VAC x 6	séquentielle 50	91	13m	10m	0,02
Carlson, 1991	CPA-CCNU-VCR-CDDP~VP16-ADR-MTX x 7-10	consolidation 55	48	20m	19m	0,91
Johnson, 1993	VAC x 6	concomitante 45	369	14m	13m	0,08
Lebeau, 1993	CPA-ADR-CCNU~ VP16-ADR-CDDP x 8	séquentielle 46	35			0,96
Joss, 1994	CDDP ou CPA-ADR-VP16 ou ~	séquentielle 45	?	363j	316j	0,86

Références

(1) Fox RM, Woods RL, Brodie GN, Tattersall MH. A randomized study: small cell anaplastic lung cancer treated by combination chemotherapy and adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 1980; 6(8):1083-1085.

(2) Souhami RL, Geddes DM, Spiro SG, Harper PG, Tobias JS, Mantell BS et al. Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. Br Med J (Clin Res Ed) 1984; 288(6431):1643-1646.

(3) Osterlind K, Hansen HH, Hansen HS, Dombernowsky P, Hansen M, Rorth M. Chemotherapy versus chemotherapy plus irradiation in limited small cell lung cancer. Results of a controlled trial with 5 years follow-up. Br J Cancer 1986; 54(1):7-17.

(4) Ohnoshi T, Hiraki S, Kawahara S, Yamashita H, Yonei T, Ishii J et al. Randomized trial comparing chemotherapy alone and chemotherapy plus chest irradiation in limited stage small cell lung cancer: a preliminary report. Jpn J Clin Oncol 1986; 16(3):271-277.

(5) Bunn PAJ, Lichter AS, Makuch RW, Cohen MH, Veach SR, Matthews MJ et al. Chemotherapy alone or chemotherapy with chest radiation therapy in limited stage small cell lung cancer. A prospective, randomized trial. Ann Intern Med 1987; 106(5):655-662.

(6) Perry MC, Eaton WL, Propert KJ, Ware JH, Zimmer B, Chahinian AP et al. Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung. N Engl J Med 1987; 316(15):912-918.

(7) Kies MS, Mira JG, Crowley JJ, Chen TT, Pazdur R, Grozea PN et al. Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced- field radiation in partial responders: a Southwest Oncology Group Study. J Clin Oncol 1987; 5(4):592-600.

(8) Nou E, Brodin O, Bergh J. A randomized study of radiation treatment in small cell bronchial carcinoma treated with two types of four-drug chemotherapy regimens. Cancer 1988; 62(6):1079-1090.

(9) Birch R, Omura GA, Greco FA, Perez CA. Patterns of failure in combined chemotherapy and radiotherapy for limited small cell lung cancer: Southeastern Cancer Study Group experience. NCI Monogr 1988;(6):265-270.

(10) Kraft A, Arnold H, Zwingers T, Bodemann H, von Bultzingslowen F, Hinkelbein W et al. Role of thoracic radiotherapy combined with chemotherapy in limited stage small cell lung cancer (SCLC). A randomized multicenter phase III trial. Onkologie 1990; 13(4):253-258.

(11) Carlson RW, Sikic BI, Gandara DR, Hendrickson CG, Wittlinger PS, Shields JA et al. Late consolidative radiation therapy in the treatment of limited-stage small cell lung cancer. Cancer 1991; 68(5):948-958.

(12) Johnson DH, Bass D, Einhorn LH, Crawford J, Perez CA, Bartolucci A et al. Combination chemotherapy with or without thoracic radiotherapy in limited-stage small-cell lung cancer: a randomized trial of the Southeastern Cancer Study Group. J Clin Oncol 1993; 11(7):1223-1229.

(13) Lebeau B, Chastang C, Brechot JM, Capron F. A randomized trial of delayed thoracic radiotherapy in complete responder patients with small-cell lung cancer. Petites Cellules Group. Chest 1993; 104(3):726-733.

(14) Joss RA, Alberto P, Bleher EA, Ludwig C, Siegenthaler P, Martinelli G et al. Combined-modality treatment of small-cell lung cancer: randomized comparison of three induction chemotherapies followed by maintenance chemotherapy with or without radiotherapy to the chest. Swiss Group for Clinical Cancer Research (SAKK). Ann Oncol 1994; 5(10):921-928.